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model rapamycin  (MedChemExpress)


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    MedChemExpress model rapamycin
    Model Rapamycin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1351 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 96 stars, based on 1351 article reviews
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    Fig. 1. mTOR complex organization and functions. mTOR plays its role in signal integration through two distinct complexes (mTORC1 and mTORC2). Each of these compo- nents is responsible for transducing appropriate signals into distinct responses.

    Journal: Journal of theoretical biology

    Article Title: Dynamic modeling of signal transduction by mTOR complexes in cancer.

    doi: 10.1016/j.jtbi.2019.109992

    Figure Lengend Snippet: Fig. 1. mTOR complex organization and functions. mTOR plays its role in signal integration through two distinct complexes (mTORC1 and mTORC2). Each of these compo- nents is responsible for transducing appropriate signals into distinct responses.

    Article Snippet: Contents lists available at ScienceDirect Journal of Theoretical Biology journal homepage: www.elsevier.com/locate/jtb Dynamic modeling of signal transduction by mTOR complexes in cancer Mohammadreza Dorvash a , b , 1 , Mohammad Farahmandnia b , c , 1 , Pouria Mosaddeghi a , b , c , 1 , Mitra Farahmandnejad a , b , c , Hosein Saber a , c , Mohammadhossein Khorraminejad-Shirazi b , c , Amir Azadi a , d , Iman Tavassoly e , ∗ a Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran b Cell and Molecular Medicine Student Research Group, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran c Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran d Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran e Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA a r t i c l e i n f o Article history: Received 10 May 2019 Revised 5 August 2019 Accepted 2 September 2019 Available online 4 September 2019 Keywords: Cell Signaling Mathematical Model mTOR Rapamycin Systems Biology Systems pharmacology a b s t r a c t Signal integration has a crucial role in the cell fate decision and dysregulation of the cellular signaling pathways is a primary characteristic of cancer.

    Techniques:

    Fig. 2. The schematic interaction diagram representing the mechanism of inhibition of mTOR by rapamycin. (Thicker arrows represent higher rate constant for that direction).

    Journal: Journal of theoretical biology

    Article Title: Dynamic modeling of signal transduction by mTOR complexes in cancer.

    doi: 10.1016/j.jtbi.2019.109992

    Figure Lengend Snippet: Fig. 2. The schematic interaction diagram representing the mechanism of inhibition of mTOR by rapamycin. (Thicker arrows represent higher rate constant for that direction).

    Article Snippet: Contents lists available at ScienceDirect Journal of Theoretical Biology journal homepage: www.elsevier.com/locate/jtb Dynamic modeling of signal transduction by mTOR complexes in cancer Mohammadreza Dorvash a , b , 1 , Mohammad Farahmandnia b , c , 1 , Pouria Mosaddeghi a , b , c , 1 , Mitra Farahmandnejad a , b , c , Hosein Saber a , c , Mohammadhossein Khorraminejad-Shirazi b , c , Amir Azadi a , d , Iman Tavassoly e , ∗ a Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran b Cell and Molecular Medicine Student Research Group, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran c Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran d Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran e Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA a r t i c l e i n f o Article history: Received 10 May 2019 Revised 5 August 2019 Accepted 2 September 2019 Available online 4 September 2019 Keywords: Cell Signaling Mathematical Model mTOR Rapamycin Systems Biology Systems pharmacology a b s t r a c t Signal integration has a crucial role in the cell fate decision and dysregulation of the cellular signaling pathways is a primary characteristic of cancer.

    Techniques: Inhibition

    Fig. 3. Temporal concentration of rapamycin for regimens I–IV. Since the plasma protein binding of the rapamycin is set aside, the concentration of free Cytosolic rapamycin is equal to its total concentration. Each regimen is simulated while scanning the “amount ± 20%” area (linearly stepped) around the dose administered. (A) Regimen Ⅰ : 8.0 × 10 −20 ± 20% mole/Day; (B) Regimen Ⅱ : 5.6 × 10 −19 ± 20% mole/Day; (C) Regimen Ⅲ : 5.6 × 10 −19 ± 20% mole/Week; and (D) Regimen Ⅳ : 2.24 × 10 −18 ± 20% mole/ Week.

    Journal: Journal of theoretical biology

    Article Title: Dynamic modeling of signal transduction by mTOR complexes in cancer.

    doi: 10.1016/j.jtbi.2019.109992

    Figure Lengend Snippet: Fig. 3. Temporal concentration of rapamycin for regimens I–IV. Since the plasma protein binding of the rapamycin is set aside, the concentration of free Cytosolic rapamycin is equal to its total concentration. Each regimen is simulated while scanning the “amount ± 20%” area (linearly stepped) around the dose administered. (A) Regimen Ⅰ : 8.0 × 10 −20 ± 20% mole/Day; (B) Regimen Ⅱ : 5.6 × 10 −19 ± 20% mole/Day; (C) Regimen Ⅲ : 5.6 × 10 −19 ± 20% mole/Week; and (D) Regimen Ⅳ : 2.24 × 10 −18 ± 20% mole/ Week.

    Article Snippet: Contents lists available at ScienceDirect Journal of Theoretical Biology journal homepage: www.elsevier.com/locate/jtb Dynamic modeling of signal transduction by mTOR complexes in cancer Mohammadreza Dorvash a , b , 1 , Mohammad Farahmandnia b , c , 1 , Pouria Mosaddeghi a , b , c , 1 , Mitra Farahmandnejad a , b , c , Hosein Saber a , c , Mohammadhossein Khorraminejad-Shirazi b , c , Amir Azadi a , d , Iman Tavassoly e , ∗ a Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran b Cell and Molecular Medicine Student Research Group, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran c Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran d Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran e Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA a r t i c l e i n f o Article history: Received 10 May 2019 Revised 5 August 2019 Accepted 2 September 2019 Available online 4 September 2019 Keywords: Cell Signaling Mathematical Model mTOR Rapamycin Systems Biology Systems pharmacology a b s t r a c t Signal integration has a crucial role in the cell fate decision and dysregulation of the cellular signaling pathways is a primary characteristic of cancer.

    Techniques: Concentration Assay, Clinical Proteomics, Protein Binding

    Fig. 5. Temporal concentration of rapamycin, mTORC1, and mTORC2 for different absorption and elimination rate constants (macro-constants) of rapamycin: the K abs@Rapam and K el@Rapam were scanned jointly in an area within a percentage range logarithmically spaced from −2 logs to + 2 logs using three steps each, making nine possible combinations for these kinetic parameters. The reference dose used for this parameter scan is 5.0 × 10 −19 mole/Day (regimen Ⅱ ). The plot at the center is where the K abs@Rapam and K el@Rapam are at their initial values. (K abs@Rapam = absorption rate constant; K el@Rapam = elimination rate constant).

    Journal: Journal of theoretical biology

    Article Title: Dynamic modeling of signal transduction by mTOR complexes in cancer.

    doi: 10.1016/j.jtbi.2019.109992

    Figure Lengend Snippet: Fig. 5. Temporal concentration of rapamycin, mTORC1, and mTORC2 for different absorption and elimination rate constants (macro-constants) of rapamycin: the K abs@Rapam and K el@Rapam were scanned jointly in an area within a percentage range logarithmically spaced from −2 logs to + 2 logs using three steps each, making nine possible combinations for these kinetic parameters. The reference dose used for this parameter scan is 5.0 × 10 −19 mole/Day (regimen Ⅱ ). The plot at the center is where the K abs@Rapam and K el@Rapam are at their initial values. (K abs@Rapam = absorption rate constant; K el@Rapam = elimination rate constant).

    Article Snippet: Contents lists available at ScienceDirect Journal of Theoretical Biology journal homepage: www.elsevier.com/locate/jtb Dynamic modeling of signal transduction by mTOR complexes in cancer Mohammadreza Dorvash a , b , 1 , Mohammad Farahmandnia b , c , 1 , Pouria Mosaddeghi a , b , c , 1 , Mitra Farahmandnejad a , b , c , Hosein Saber a , c , Mohammadhossein Khorraminejad-Shirazi b , c , Amir Azadi a , d , Iman Tavassoly e , ∗ a Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran b Cell and Molecular Medicine Student Research Group, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran c Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran d Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran e Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA a r t i c l e i n f o Article history: Received 10 May 2019 Revised 5 August 2019 Accepted 2 September 2019 Available online 4 September 2019 Keywords: Cell Signaling Mathematical Model mTOR Rapamycin Systems Biology Systems pharmacology a b s t r a c t Signal integration has a crucial role in the cell fate decision and dysregulation of the cellular signaling pathways is a primary characteristic of cancer.

    Techniques: Concentration Assay